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Photo: Innovent e.V. Technologieentwicklung Jena
Photo: Innovent e.V. Technologieentwicklung Jena

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Exhibit: Antimicrobial wound dressing

Most of commercially available silver containing wound dressings contains a high silver concentration of more than 10 mg on an area of 10 x 10 cm2. Furthermore, in context with wound dressings alternative active agents mostly are not available.

INNOVENT is able to produce functional coatings on different surfaces by using the so-called atmospheric pressure plasma chemical vapour deposition technique. This technique allows to deposit very thin glass-like coatings and to embed certain functional agents into the growing film matrix directly during the coating process.

Here this is shown for a silver-containing wound dressing material. Concretely, a PA6/viscose material is presented which is coated with an about 50 nm transparent silicon oxide thin film. In the coating silver was embedded with a concentration necessary to obtain antimicrobial properties. Compared to established preparation methods here it is advantageous that the silver concentration is lowered to less than 5 mg per 10 x 10 cm2. Furthermore, the silver is located where it is needed – at the wound dressing surface. In spite of the lowered agent concentration the antimicrobial efficiency is on the same level compared to other commercially available products.

Further advantages are the universally applicable deposition method useful to practically every wound dressing material, a low but sufficient agent concentration, an excellent antimicrobial efficiency against a lot of microorganism and a non-cytotoxic behaviour against skin cells.

The coating method allows to embed alternative active agents like copper or zinc into the glass-like silicon oxide coatings with a comparable antimicrobial performance.

The strong antimicrobial efficiency was demonstrated by using BTG and CFU test methods on Escherichia coliHB101 (-), the pathogen germs Klebsiella pneumoniaeATCC 4352 (-), Staphylococcus aureusATCC 6538 (+) and Staphylococcus aureusATCC 33591 (+) (MRSA).

The coating can be sterilised by common techniques and can be applied on different materials like textiles, polymers, metals as well as glass or wood.

Literature:

S. Spange, A. Pfuch, C. Wiegand, O. Beier, U.C. Hipler, B. Grünler; „Atmospheric pressure plasma CVD as a tool to functionalise wound dressings”, Journal of Materials Science: Materials in Medicine (2015) 26 (2), 76, DOI 10.1007/s10856-015-5417-3

We are looking forward to your requests on antimicrobial coatings!

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